Committed to the patient

Development, regulation and global marketing of the drug from start to finish.

Our mission is to improve people's health and quality of life through the manufacture of highly complex and accessible injectable products.

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Our Purpose

To improve people’s health and quality of life through the manufacture of highly complex injectable products, accessible to all in a sustainable manner and reducing our environmental impact.

We seek to be a benchmark of reliability and reputation for patients and partners at national and international levels.

Research and talent to bring science to society

Our culture is based on:

Innovation

Generating advances to improve patients’ lives and contribute to the progress of the pharmaceutical industry.

Achievement

Always driving excellence.

One Team

Strengthening talent and internal collaboration for the development of a great team.

History of GP Pharm

Research, development, and innovation

The research and development team at GP Pharm is highly specialized in drug encapsulation using microspheres, liposomes, and lipid nanoparticles.

We have extensive experience in the development and manufacture of injectable pharmaceutical products with these types of technology platforms and the encapsulation of peptides, oligonucleotides, mRNA, and other active substances.

Our development and research laboratories are equipped with the latest chromatographic technologies such as HPLC, UPLC, and quantitative HPTLC. Additionally, we have DSC calorimeter, KF for water content determination, DLS for particle size analysis in the submicron range and zeta potential with dynamic light scattering, LS for particle size analysis in the micron range or larger, polymer analysis by GPC, viscometric analysis, UV, FT-IR, GC, among other specific analytical technologies.

Thanks to these tools, we can ensure rapid and reliable results at the different stages of development of its pharmaceutical products, including monitoring of scale-up processes from the laboratory to the manufacture of commercial batches.

Prolonged and controlled drug release systems allow for a reduction in the effective dose received by the patient, improving the efficacy and safety of the drug.

This is the result of R efforts in the technological areas of sustained drug release systems. GP Pharm can develop new generations of conventional pharmaceutical products through microencapsulation of the active ingredient in microspheres and liposomes.

Sustained and controlled drug delivery systems

Generally, pharmaceutical products must be administered several times a day over a certain period of time in order to achieve a constant pharmacological effect.

This dosing pattern may result in poor control of blood drug levels, leading to fluctuations in concentration that may occasionally fall below therapeutic efficacy values or rise above toxicity levels for the drug in question. Especially for products with high pharmacological potency, this may lead to undesirable side effects for the patient.

Our sustained and controlled release systems for drugs make it possible to administer high-potency substances over long periods of time and with better control of drug release than with traditional delivery systems.

The main objectives of these new systems are: to reduce undesirable side effects, increase the time between doses, and achieve comprehensive control of drug release.

Technology Platforms

We deliver drugs through:

Microspheres
Microspheres
Microspheres

The main method for achieving controlled release of the active substance is to incorporate it into a biodegradable polymeric assembly called a microcapsule.

In microencapsulated drugs, the active substance is trapped in a polymeric matrix or covered and/or coated by a polymeric shell. When the product formation process results in the formation of small spherical particles, these are called microspheres.

GP Pharm’s technological capabilities in the field of microspheres:

  • Obtaining microspheres through different technologies: simple emulsion, double emulsion, and coacervation.
  • Proprietary and patented technology for modulating drug release from microspheres.
  • Experience in the manufacture of water- and fat-soluble products through the use of different types of additives on the capsule surface.
  • Experience in the use of biopolymers of synthetic and natural origin.
  • Capacity to manufacture microspheres in the range of 5 to 200 µm.
  • Ability to obtain controlled release formulas from 5-6 days to 6 months.
  • Solid and proven experience in process scale-up from laboratory to industrial level.
  • GP Pharm develops and patents its own microsphere-based innovations.
Liposomes
Liposomes

Liposomes are thermodynamically stable vesicular structures composed of lipid bilayers of amphiphilic lipids.

Are formed spontaneously by the dispersion of phospholipids in an aqueous medium and can be described as spherical, closed structures of submicron dimensions formed by one or more concentric lipid bilayers containing aqueous spaces between them. 



Liposomes have great potential as controlled drug delivery systems for parenteral administration thanks to their unique properties that allow the encapsulation of water- and fat-soluble substances. Therefore, it is an ideal delivery system for controlled releases with times of 1 to 4 days.

Thanks to their structure and design based on lipid components, liposomes are biocompatible, biodegradable, and non-toxic. Their application as controlled drug delivery systems has been extensively studied, for example, for the administration of antitumor drugs, antibacterial and antiviral treatments, and as an immunological adjuvant in vaccines and, more recently, in gene therapy. In addition, they are also used in the field of cosmetics, diagnostics, and the food industry.

GP Pharm's technological capabilities in the field of liposomes:

  • Development of in vitro release tests in different buffer solutions and in human plasma.
  • Characterization of liposomes by electron microscopy, cryo-electron microscopy, TEM, and SEM.
  • Characterization of drugs in liposomes by circular dichroism and X-rays.
  • DSC for the determination of transition temperatures.
  • Determination of collapse temperatures for the development of lyophilized liposome formulations.
  • Development of lyophilization processes for liposomal formulations.
  • Solid and proven experience in process scale-up from laboratory to industrial level.
  • GP Pharm develops and patents its own liposome-based innovations.
Nanoencapsulation
Nanoencapsulation

New Types of Formulations and Technology Platforms

Our extensive experience in the development and production of finished products (lyophilized powders, solutions, microspheres, and liposomes) containing active ingredients such as peptides, DNA, RNA, HPAPIs, and cytotoxic agents, among others, opens up enormous potential for the development of new, improved formulations with greater stability, better suitability for patients, and more controlled drug release.

Currently, new technological pathways based on nanotechnology have been developed to obtain new types of enhanced lipid nanoparticles, such as lipid nanoparticles (LNPs), nanostructured lipid carriers like solid lipid nanoparticles (SLNs) or lipid nanocarriers (NLCs), and lipid-drug conjugates (LDCs).

GP Pharm's industrial facilities are located in an area of 35,000 square meters in Sant Quintí de Mediona

Industrial Facilities

Our industrial facilities are located in an area of 35,000 square meters in Sant Quintí de Mediona (approximately 50 km west of Barcelona).

Inaugurated in 2005, the project was designed considering possible growth of the facilities in parallel with that of the company. In fact, in 2017 part of the facilities was expanded and renovated to double manufacturing capacity and adapt to growing demand. Currently, they occupy 5.447 m² and the facility has 8 buildings, of which 3 are exclusively dedicated to the manufacture of pharmaceutical products. The rest are used for offices, laboratories, logistics, and supplies.

Areas of Specialization

Areas of Specialization
Medical Department

The medical department designs, conducts, and coordinates the complete clinical development of our pharmaceutical products. The extensive know-how of our team in all areas of this process ensures proper development from preclinical phase to phase IV studies, ensuring quality control.

They are also specialized in Medical Affairs, being a pillar for product strategy and providing high value in scientific communication with all stakeholders, including national and international Regulatory Agencies.

Our team has extensive experience—academic profiles with master’s and doctoral degrees—in the validation, design, and conduct of clinical studies, generation of scientific evidence, medical positioning of our products, communication, and scientific training. These functions mean that it works in constant collaboration with the different departments of the company, providing support to, among others, pharmacovigilance, market access, and regulatory aspects.

Our cornerstone is to ensure the health and well-being of patients from the early stages of research to clinical practice.

We develop innovative products and technologies in the field of the pharmaceutical industry. In order to protect the important value of the Company’s intellectual property generated in its laboratories, we create a comprehensive international patent portfolio.

In GP Pharm we own more than 100 patents and patent applications in more than 50 countries, protecting key products and technologies including, among others, controlled drug delivery system formulations.

Our supply chain for pharmaceutical products is perfectly integrated: reception, identification, storage, order preparation, documentation, shipping, and distribution are perfectly monitored to have perfect traceability of product shipment to the customer and ensure the quality and storage of the same under authorized conditions.

The company has extensive experience in shipping temperature-controlled products to anywhere in the world including ambient temperature (<25°C), cold (between 2 and 8°C), and/or below zero (-20°C). We work with the best suppliers of active and passive temperature control systems, carefully choosing the most appropriate one according to the shipping system to guarantee the quality of the final product at destination.

The company assumes responsibility for the preparation of export documentation in accordance with the different regulations of each country to facilitate the import process by the customer and expedite shipping.

Our customer service, both nationally and internationally, performs complete monitoring of all sales processes, from the moment the order is received until its delivery, to guarantee the best service and satisfaction to our customers. In this regard, we are committed to providing an exceptional level of service through our attention to detail and a deep understanding of the needs of each of our customers.

Our Regulatory Affairs team has extensive experience in registration procedures worldwide, especially at the European level (NP, DCP, CP, MRP) and the USA. It also has extensive experience in supporting registration procedures in other territories such as Canada, Australia, ASEAN, APAC, MENA, LATAM, among others.


Our main capabilities include:

  • Preparation of new dossiers in e-CTD format
  • Audits of registration dossiers and DMFs.
  • Processing of authorization processes and updating of registration dossiers in different regions.
  • Support to clients in regulatory procedures in different territories.

The Pharmacovigilance team works to ensure the safety and efficacy of our medicines, during development, commercialization, and throughout the product life cycle, monitoring adverse effects linked to our medicines and complying with the health obligations associated with pharmacovigilance.

Affiliations

Biocat
Catalonia Health - Science. Innovation. Business
UNIÓ EMPRESARIAL DEL PENEDÉS